The Hairless Gene Mutated in Congenital Hair Loss Disorders Encodes a Novel Nuclear Receptor Corepressor

October 2001 in “ Genes & Development ”

Gregory B. Potter, Gerard M. J. Beaudoin, Cynthia DeRenzo, Joanna M. Zarach, Steve H. Chen, Catherine C. Thompson

hairless gene congenital hair loss disorders nuclear receptor corepressor thyroid hormone receptors transcriptional corepressor histone deacetylases matrix-associated deacetylase bodies

Studysummary This study found that the mammalian hairless gene encodes a corepressor protein that interacts with thyroid hormone receptors, providing insights into hair loss syndromes in humans and mice.

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Research cited in this study

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research A Novel Missense Mutation (C622G) in the Zinc-Finger Domain of the Human Hairless Gene Associated with Congenital Atrichia with Papular Lesions

47 citations , April 2000 in “Experimental Dermatology”

This study identified a novel missense mutation in the hairless gene in a Polish family, which may contribute to congenital atrichia with papular lesions by affecting the gene's function.

research Novel Hairless Mutations in Two Kindreds with Autosomal Recessive Papular Atrichia

66 citations , December 1999 in “Journal of Investigative Dermatology”

New mutations in the hairless gene may cause hair loss and affect bone development.

research The Hairless Gene of the Mouse: Relationship of Phenotypic Effects with Expression Profile and Genotype

52 citations , October 1999 in “Developmental Dynamics”

This study found that the hairless gene in mice has a more extensive role in development than previously thought, as indicated by its expression in various tissues and associated abnormalities in hr/hr mutants.

research The Role of the Hairless (Hr) Gene in the Regulation of Hair Follicle Catagen Transformation

166 citations , July 1999 in “American Journal Of Pathology”

This study found that the loss of a functional hr gene in mice leads to premature and abnormal hair follicle regression, disrupting normal hair cycling and architecture.

research Molecular and Functional Aspects of the Hairless (Hr) Gene in Laboratory Rodents and Humans

126 citations , October 1998 in “Experimental Dermatology”

This review provides an overview of the hairless gene in mice and humans, discussing its structure, expression, and implications for understanding skin physiology and human disorders related to gene disruption, but it reports no new empirical findings.

research Alopecia Universalis Associated With a Mutation in the Human Hairless Gene

412 citations , January 1998 in “Science”

This study identified a missense mutation in the human hairless gene associated with a rare form of recessively inherited alopecia universalis, pinpointed on chromosome 8p12.