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    Glossary Histone Deacetylases

    enzymes that remove acetyl groups from histone proteins

    Histone Deacetylases (HDACs) are enzymes that remove acetyl groups from histone proteins, leading to a more compact and less accessible form of DNA. This process can suppress gene expression by making it harder for transcription factors to access the DNA. HDACs play a crucial role in regulating gene activity and are involved in various biological processes, including cell cycle progression and differentiation.

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    1. Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis Journal of Investigative Dermatology · 2013 · 32 citations
    2. Sodium Valproate Improves Skin Flap Survival via Gamma-Aminobutyric Acid and Histone Deacetylase Inhibitory System 2019 · 8 citations
    3. Histone deacetylase 1 in patients with alopecia areata and acne vulgaris: An epigenetic alteration Australasian Journal of Dermatology · 2022 · 4 citations
    4. Histone deacetylase inhibitors promote neurosteroid‐mediated cell differentiation and enhance serotonin‐stimulated brain‐derived neurotrophic factor gene expression in rat C6 glioma cells Journal of Neuroscience Research · 2009 · 35 citations
    5. Nerve-mediated expression of histone deacetylases regulates limb regeneration in axolotls Developmental Biology · 2019 · 12 citations
    6. Epigenetic control of adult stem cell function Nature Reviews Molecular Cell Biology · 2016 · 179 citations
    7. The <i>hairless</i> gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor Genes & Development · 2001 · 178 citations
    8. Interactions of the Vitamin D Receptor with the Corepressor Hairless Journal of Biological Chemistry · 2007 · 42 citations
    9. Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle Journal of Cellular Biochemistry · 2010 · 22 citations
    10. Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation Proceedings of the National Academy of Sciences · 2024 · 16 citations
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