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    Glossary Histone Deacetylases

    enzymes that remove acetyl groups from histone proteins

    Histone Deacetylases (HDACs) are enzymes that remove acetyl groups from histone proteins, leading to a more compact and less accessible form of DNA. This process can suppress gene expression by making it harder for transcription factors to access the DNA. HDACs play a crucial role in regulating gene activity and are involved in various biological processes, including cell cycle progression and differentiation.

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    1. Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis Journal of Investigative Dermatology · 2013 · 32 citations
    2. Sodium Valproate Improves Skin Flap Survival via Gamma-Aminobutyric Acid and Histone Deacetylase Inhibitory System 2019 · 8 citations
    3. Histone deacetylase 1 in patients with alopecia areata and acne vulgaris: An epigenetic alteration Australasian Journal of Dermatology · 2022 · 4 citations
    4. Histone deacetylase inhibitors promote neurosteroid‐mediated cell differentiation and enhance serotonin‐stimulated brain‐derived neurotrophic factor gene expression in rat C6 glioma cells Journal of Neuroscience Research · 2009 · 35 citations
    5. Nerve-mediated expression of histone deacetylases regulates limb regeneration in axolotls Developmental Biology · 2019 · 12 citations
    6. Epigenetic control of adult stem cell function Nature Reviews Molecular Cell Biology · 2016 · 179 citations
    7. The <i>hairless</i> gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor Genes & Development · 2001 · 178 citations
    8. Interactions of the Vitamin D Receptor with the Corepressor Hairless Journal of Biological Chemistry · 2007 · 42 citations
    9. Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle Journal of Cellular Biochemistry · 2010 · 22 citations
    10. Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation Proceedings of the National Academy of Sciences · 2024 · 16 citations
    11. Inhibition of class I HDACs preserves hair follicle inductivity in postnatal dermal cells Scientific Reports · 2021 · 6 citations
    12. Mapping of cis-acting expression quantitative trait loci in human scalp hair follicles BMC Dermatology · 2020 · 4 citations
    13. Second International Symposium—Epigenetic Regulation of Skin Regeneration and Aging: From Chromatin Biology towards the Understanding of Epigenetic Basis of Skin Diseases 2017 · 2 citations
    14. Hairless: A nuclear receptor corepressor essential for skin function Advances in developmental biology · 2006
    15. Sirtuins pathways and redox homeostasis: a pilot study on young and old monozygotic twins Free Radical Biology and Medicine · 2015
    16. Short-Chain Fatty Acids from <i>Cutibacterium acnes</i> Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes 2019 · 70 citations
    17. Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness British Journal of Dermatology · 2011 · 51 citations
    18. Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients Neurobiology of Disease · 2014 · 48 citations
    19. Valproic acid promotes human hair growth in in vitro culture model Journal of Dermatological Science · 2013 · 48 citations
    20. TSA restores hair follicle-inductive capacity of skin-derived precursors Scientific Reports · 2019 · 18 citations
    21. Small RNAs Loom Large During Reprogramming Cell stem cell · 2011 · 18 citations
    22. Modulation of Vitamin D Receptor Activity by the Corepressor Hairless: Differential Effects of Hairless Isoforms Endocrinology · 2009 · 18 citations
    23. HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy Theranostics · 2024
    24. Genetics of Alopecia Encyclopedia of Life Sciences · 2012
    25. Hairless protein of Jumonji family and hair loss 2009
    26. Valproic acid and alopecia: A two-edged sword Asian Journal of Psychiatry · 2017 · 2 citations
    27. Where WNT the Hair NEJM Journal Watch · 2013
    28. SIRT1 downregulation provokes immune-inflammatory responses in hair follicle outer root sheath cells and may contribute to development of alopecia areata Journal of Dermatological Science · 2023 · 13 citations
    29. Targeting cardiac hypertrophy through a nuclear co‐repressor EMBO molecular medicine · 2019 · 3 citations
    30. Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease Genes & Development · 2008 · 667 citations