Novel Advances of Histone Modification in Inflammatory Skin Diseases and Related Treatment Methods

January 2024 in “ Frontiers in immunology ”

Lichen Zhang, Rongrong Chai, Zongguang Tai, Fengze Miao, Xinwei Shi, Zhongjian Chen, Quangang Zhu

histone modification psoriasis atopic dermatitis lupus systemic sclerosis contact dermatitis lichen planus alopecia areata epigenetic regulatory approach therapeutic interventions eczema scleroderma epigenetic regulation treatments

Studysummary This review highlights the crucial role of histone modification in the pathogenesis and treatment of chronic inflammatory skin diseases, and explores therapeutic strategies targeting these epigenetic changes to improve management of conditions such as psoriasis and atopic dermatitis.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Histone modification is crucial in the pathogenesis and treatment of chronic inflammatory skin diseases such as psoriasis, atopic dermatitis, lupus, systemic sclerosis, contact dermatitis, lichen planus, and alopecia areata. This review highlights the role of histone modification as an epigenetic regulatory approach, offering insights into managing these disorders. Therapeutic interventions targeting histone modifications show promise in effectively managing these conditions. The review also explores current and potential therapeutic strategies and emphasizes the future research prospects in this area, aiming for innovative treatments and better patient outcomes.

View this study on frontiersin.org →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Economic Burden of Alopecia Areata: A Study of Direct and Indirect Cost in Japan Using Real-World Data

2 citations , July 2023 in “Journal of dermatology”

This study reported that alopecia areata imposes a significant personal and national economic burden in Japan, with estimated total costs of 112.7 billion yen due largely to productivity loss.

research SIRT1 Downregulation Provokes Immune-Inflammatory Responses in Hair Follicle Outer Root Sheath Cells and May Contribute to Development of Alopecia Areata

13 citations , May 2023 in “Journal of Dermatological Science”

This research found that reduced expression of SIRT1 in human scalp tissue may contribute to alopecia areata development by inducing immune-inflammatory responses in hair follicle cells, suggesting that SIRT1 plays a regulatory role in hair follicle immunity.

research The Burden of Alopecia Areata: A Scoping Review Focusing on Quality of Life, Mental Health, and Work Productivity

10 citations , January 2023 in “Journal of the European Academy of Dermatology and Venereology”

This review highlights the significant negative impact of alopecia areata on quality of life, mental health, and work, calling for individualized approaches and effective treatments to mitigate these effects.

research Histone Deacetylase 1 in Patients With Alopecia Areata and Acne Vulgaris: An Epigenetic Alteration

4 citations , January 2022 in “Australasian Journal of Dermatology”

This study found that serum HDAC1 levels are significantly higher in patients with alopecia areata compared to those with acne vulgaris and healthy controls, suggesting potential therapeutic opportunities for HDAC inhibitors.

research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications

37 citations , December 2021 in “Cells”

This study found that dysregulation of systemic Th1, Th2, and Th17 cytokines is associated with alopecia areata, with specific cytokines linked to disease activity and treatment response.

research Immunology of Alopecia Areata

23 citations , November 2020 in “Central-European Journal of Immunology/Central European Journal of Immunology”

This review explores the autoimmune hypothesis of alopecia areata and the possible genetic and melanogenesis-associated autoantigens, but reports no new clinical findings.

Short-Chain Fatty Acids from Cutibacterium Acnes Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes

research Short-Chain Fatty Acids from Cutibacterium Acnes Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes

70 citations , February 2019 in “The journal of immunology/The Journal of immunology”

This study found that short-chain fatty acids produced by the skin microbe Propionibacterium acnes may drive inflammatory gene expression in sebocytes, potentially contributing to acne.

research The Autoimmune Basis of Alopecia Areata: A Comprehensive Review

162 citations , October 2014 in “Autoimmunity reviews”

This review discusses alopecia areata, highlighting its autoimmune aspects, environmental triggers, and current treatment options, but reports no new clinical results; recent studies suggest JAK pathway intervention may offer therapeutic potential.

research Abnormal Epigenetic Modifications in Peripheral Blood Mononuclear Cells from Patients with Alopecia Areata

48 citations , September 2011 in “British Journal of Dermatology”

This study found that DNA methylation and histone modification status were altered in peripheral blood mononuclear cells of patients with alopecia areata, suggesting these changes may contribute to the disease's pathological immune responses.