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Novel Advances of Histone Modification in Inflammatory Skin Diseases and Related Treatment Methods

research Noval advance of histone modification in inflammatory skin diseases and related treatment methods

January 2024 in “Frontiers in immunology”

This review highlights the crucial role of histone modification in the pathogenesis and treatment of chronic inflammatory skin diseases, and explores therapeutic strategies targeting these epigenetic changes to improve management of conditions such as psoriasis and atopic dermatitis.

research Identifying critical cell types and gene regulatory pathways for hair and skin disease

July 2023 in “Nature Genetics”

Researchers identified key cell types and genes involved in hair and skin diseases.

research A State-of-the-Art Overview on (Epi)Genomics and Personalized Skin Rejuvenating Strategies

December 2025 in “Pharmaceutics”

This review highlights new perspectives in genomics and epigenomics for skin rejuvenation, comparing innovative strategies like senolytics and DNA repair modulators with classical treatments, and emphasizing the importance of tailoring therapies using individual genomic profiles for personalized anti-ageing approaches.

All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

This review discusses the interplay between signaling/transcription factor-mediated and epigenetic mechanisms in skin development and regeneration, highlighting the need for further exploration of epigenome reorganization in these processes.

A Genomic Approach to Susceptibility and Pathogenesis Leads to Identifying Potential Novel Therapeutic Targets in Androgenetic Alopecia

research A genomic approach to susceptibility and pathogenesis leads to identifying potential novel therapeutic targets in androgenetic alopecia

13 citations , March 2017 in “Genomics”

This study reported that pathways related to apoptosis, cell proliferation, and WNT signaling might be key drivers of hair loss in androgenetic alopecia, guiding potential targets for therapy development.

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community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁

276 upvotes 6 months ago

GT20029 is a new hair loss treatment in Phase 3 trials in China, using PROTAC technology to target androgen receptors, potentially with fewer side effects than finasteride and minoxidil. VDPHL01, a second-generation minoxidil, is also mentioned as potentially more effective.

community A warning to those using or thinking about using Dutasteride – Follow-up

18 upvotes 5 years ago

The post and conversation are about the long-term side effects of using Dutasteride and Finasteride for hair loss, including issues like raised liver enzymes, high cholesterol, and loss of libido. The user advises regular blood work and careful monitoring for those using these treatments.

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