TLDR Special immune cells called Regulatory T cells help control skin inflammation and repair in various skin diseases.
The document reviewed the role of Regulatory T cells (Tregs), a significant immune cell subset in the skin, in managing inflammation and aiding in organ repair. It highlighted the specialized functions of Tregs in the skin and examined their involvement in various skin disorders, including scleroderma, alopecia areata, atopic dermatitis, cutaneous lupus erythematosus, and psoriasis. The review drew comparisons between findings from mouse models and human studies to better understand the Tregs' functions in skin health and disease.
Cited in this study
5 / 5 results
66 citations
,
June 2018 in “British journal of dermatology/British journal of dermatology, Supplement” An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.
110 citations
,
August 2017 in “Immunology” Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.
99 citations
,
July 2017 in “Clinical Reviews in Allergy & Immunology” New treatments for Alopecia Areata show promise but need to be more effective and affordable.
192 citations
,
April 2017 in “Cell host & microbe” Hair follicle development and microbes help regulatory T cells gather in newborn skin.
62 citations
,
June 2015 in “The Journal of Dermatology” People with alopecia areata have more Th17 cells and fewer Treg cells, which may be key to the condition's development.
