The Expanding Impact of T-Regulatory Cells in Skin Health
September 2022
in “
Frontiers in Immunology
”
T-regulatory cells T-regs hair follicle growth skin inflammation immune homeostasis hair follicle stem cell proliferation wound healing tissue repair hair follicles regeneration adaptive immune cells alopecia areata IL-2 treatment hair growth skin health immune balance hair stem cells hair regeneration immune cells hair loss interleukin-2 treatment
TLDR T-regulatory cells are important for skin health and can affect hair growth and reduce skin inflammation.
The document discusses the significant role of T-regulatory cells (T-regs) in skin health, particularly in relation to hair follicle growth and skin inflammation. T-regs are crucial for maintaining immune homeostasis in the skin, and their numbers peak during hair follicle stem cell proliferation and hair growth. They also play a role in wound healing and tissue repair. T-regs have been found to regulate the regeneration of hair follicles and control adaptive immune cells in the skin. Disruptions in T-regs or their downstream effectors have been linked to various skin conditions, including alopecia areata, where T-regs are reduced and unable to perform suppressive functions. Treatments that boost T-regs, such as IL-2 treatment, have shown promising results in hair regeneration in patients with alopecia areata. The document suggests that further understanding of T-regs could open new avenues for therapeutic intervention in many common inflammatory skin diseases.
