TLDR Cellular and immunotherapies show promise for healing chronic wounds but need more research.
The document reviews the potential of cellular therapeutics and immunotherapies in enhancing wound healing, particularly for chronic and complex wounds. It highlights the roles of various stem cells, growth factors, and immune cells, such as mesenchymal stem cells (MSCs), adipose-derived stem cells (ADSCs), induced pluripotent stem cells (iPSCs), and regulatory T cells (T-regs). These therapies show promise in promoting tissue regeneration, reducing inflammation, and accelerating healing. However, challenges like biofilm presence, immune-related adverse events, and the need for optimized delivery systems remain. The review suggests that combining these innovative therapies with traditional treatments could revolutionize wound care and improve patient outcomes. Further research is needed to address these challenges and ensure the safety and efficacy of these therapies.
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