Regulatory T Cells Are Required for Normal and Activin-Promoted Wound Repair in Mice

The document reports on a study that investigated the role of regulatory T cells (Tregs) in wound healing in mice. The study involved three independent experiments with 7-8 mice per genotype and treatment group, resulting in 14-16 wounds analyzed per group. It was found that depletion of Tregs led to impaired wound healing, characterized by delayed re-epithelialization, reduced wound contraction, and impaired vessel maturation. This was associated with an increase in pro-inflammatory cytokines and an overrepresentation of aß T cells with Th1 and Th2 features. The study concluded that Tregs are crucial for normal and activin-enhanced wound repair, as they prevent the accumulation of pro-inflammatory aß T cells that disrupt the healing process. Statistical analysis was performed using 2-way ANOVA and Dunnett's test, confirming the significance of the findings.