TLDR Immune-epithelial interactions are crucial for tissue repair, but unchecked can cause diseases.
This document discusses the critical role of immune-epithelial cross talk in the regeneration and repair of epithelial tissues, such as skin and gut, which are essential for maintaining barrier functions and healing after injury. It highlights that epithelial regeneration and repair are closely linked with immune responses, with clinical and experimental data showing that reparative and inflammatory processes are interconnected. The review emphasizes the importance of immunological signals in maintaining epithelial homeostasis and the contribution of immune cells to different repair phases. However, when immune-mediated repair is unchecked, it can lead to epithelial pathologies like cancer, psoriasis, and inflammatory bowel diseases. Understanding these processes could lead to advancements in regenerative medicine and treatments for epithelial inflammatory diseases.
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