TLDR Macrophage iron release is crucial for hair growth and wound healing.
The study concluded that macrophage ferroportin (FPN) was essential for stromal cell proliferation and effective wound healing. Using mouse models, researchers found that the absence of FPN in macrophages led to iron retention, decreased epithelial cell proliferation, impaired hair follicle growth, transient alopecia, and delayed wound healing. This highlighted the critical role of macrophage-derived iron in tissue homeostasis and regeneration, particularly in hair follicle cycling and wound repair, suggesting potential therapeutic targets for improving wound healing outcomes.
175 citations
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December 2014 in “PLoS Biology” Macrophages help activate hair follicle stem cells, affecting hair growth and skin repair.
8 citations
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October 2012 in “Transgenic Research” Overexpressing the human H-ferritin gene in mice causes mild growth delay and temporary hair loss.
February 2018 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)” Ferroportin in macrophages is crucial for hair growth and skin healing by managing iron distribution.
2 citations
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April 2025 in “Biomedicine & Pharmacotherapy” Copper-quercetin complexes could be effective in treating cancer, infections, and promoting bone healing.
10 citations
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September 2023 in “Metabolites” Iron is crucial for skin health, with specific proteins recycling it to support skin functions and prevent its release.
November 2020 in “IntechOpen eBooks” Not getting enough minerals can lead to health problems and shorter lifespans.
7 citations
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July 2012 in “Regenerative Medicine” New treatments for diabetes, central nervous system repair, and cartilage injury were found, and a way to create functional hair follicles from stem cells was developed.
