Macrophage Ferroportin Is Essential for Stromal Cell Proliferation in Wound Healing

The study concluded that macrophage ferroportin (FPN) was essential for stromal cell proliferation and effective wound healing. Using mouse models, researchers found that the absence of FPN in macrophages led to iron retention, decreased epithelial cell proliferation, impaired hair follicle growth, transient alopecia, and delayed wound healing. This highlighted the critical role of macrophage-derived iron in tissue homeostasis and regeneration, particularly in hair follicle cycling and wound repair, suggesting potential therapeutic targets for improving wound healing outcomes.