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GlossaryMacrophages

cells that engulf and digest pathogens and debris

Macrophages are a type of white blood cell that play a crucial role in the immune system by engulfing and digesting cellular debris, pathogens, and other foreign substances. They are essential for both initiating immune responses and aiding in tissue repair, making them key players in maintaining overall health and combating infections.

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research Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

222 citations, August 2014 in “Cell Metabolism”

Mitochondrial Complex I reduces inflammation and increases bone breakdown by affecting certain immune cells.

research Macrophages Regulate Schwann Cell Maturation After Nerve Injury

130 citations, September 2018 in “Cell Reports”

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

research Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF

117 citations, March 2017 in “Nature Communications”

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

research The Role of Macrophages in Skin Homeostasis

65 citations, February 2017 in “Pflügers Archiv - European Journal of Physiology”

Macrophages are vital for skin healing, hair growth, salt balance, and cancer defense.

Bioactive Anti-Inflammatory Antibacterial Hemostatic Citrate-Based Dressing With Macrophage Polarization Regulation for Accelerating Wound Healing and Hair Follicle Neogenesis

research Bioactive Anti-Inflammatory Antibacterial Hemostatic Citrate-Based Dressing With Macrophage Polarization Regulation for Accelerating Wound Healing and Hair Follicle Neogenesis

61 citations, September 2020 in “Bioactive Materials”

A special dressing called FEA-PCEI can speed up wound healing, reduce scars, and help grow new hair follicles, but only at the right dosage.

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community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 3 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Verteporfin and Microneedling

in Treatments 6 months ago

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.