The Regenerative Potential of Skin and the Immune System

    July 2019 in “ Clinical Cosmetic and Investigational Dermatology ”
    Anna Tsepkolenko, В. О. Цепколенко, Sabyasachi Dash, A. Mishra, Augustinus Bader, Alexander Melerzanov, Shibashish Giri
    TLDR The skin's immune system helps it regenerate and fight infections.
    The document discussed the regenerative potential of the skin and its immune system, emphasizing the complex interplay of various immune cells in skin healing and immune response. It highlighted the roles of fibroblasts, mesenchymal stromal cells, dendritic cells, monocytes, macrophages, neutrophils, and other immune cells in maintaining skin integrity and responding to injury. The Wnt signaling pathway was identified as crucial for skin cell differentiation, suggesting therapeutic targets. The study also noted the development of bioengineered products to enhance skin regeneration and the potential for novel therapeutic interventions. Understanding the interactions between skin-resident and infiltrating immune populations was seen as key to developing new therapeutics for skin-related immune disorders and improving skin's regenerative potential.
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