Topical Drug Delivery Strategies for Enhancing Drug Effectiveness by Skin Barriers, Drug Delivery Systems, and Individualized Dosing

    January 2024 in “ Frontiers in Pharmacology ”
    Lin Zhao, Jia‐Mei Chen, Bai Bai … Guanghua Lu
    Studysummary This paper reviews strategies to enhance the effectiveness of topical drug delivery by addressing skin barrier challenges, optimizing drug delivery systems, and personalizing treatment approaches, highlighting both current advancements and limitations in the field.
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    Research cited in this study 7

    1. Commensal Microbiome Promotes Hair Follicle Regeneration by Inducing Keratinocyte HIF-1α Signaling and Glutamine Metabolism Science Advances · 2023
    2. Sebaceous Immunobiology: Skin Homeostasis, Innate Immunity Coordination, Inflammatory Response, and Disease Associations Frontiers in immunology · 2022
    3. TREM2 Macrophages Induced by Human Lipids Drive Inflammation in Acne Lesions Science Immunology · 2022
    4. Therapeutic Application of Microsponges-Based Drug Delivery Systems Current pharmaceutical design · 2022
    5. Bacteria Induce Skin Regeneration via IL-1β Signaling Cell Host & Microbe · 2021
    6. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    7. Subpopulations of Dermal Skin Fibroblasts Secrete Distinct Extracellular Matrix: Implications for Using Skin Substitutes in the Clinic British Journal of Dermatology · 2017