TLDR TREM2 macrophages and unsaturated lipids contribute to acne inflammation.
The study investigates the role of TREM2 macrophages in acne, a condition affecting 1 in 10 people globally. Using advanced RNA sequencing techniques, researchers found that TREM2 macrophages, which express lipid metabolism and proinflammatory genes, are located near hair follicles producing squalene. In vitro experiments showed that squalene promotes the differentiation of these macrophages, which are ineffective at killing Cutibacterium acnes. Squalene also inhibits oxidative enzymes and scavenges free radicals, explaining why benzoyl peroxide is effective in treating acne. The findings suggest that TREM2 macrophages and unsaturated lipids contribute to acne pathogenesis, similar to their role in atherosclerosis.
6 citations,
February 2021 in “Frontiers in Cell and Developmental Biology” Eating too much or too little vitamin A can cause hair loss.
101 citations,
March 2019 in “Cell Stem Cell” Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.
3 citations,
September 2023 in “Frontiers in immunology” Chronic inflammatory skin diseases are caused by disrupted interactions between skin cells and immune cells.
February 2024 in “International journal of molecular sciences” Type 3 Innate Lymphoid Cells help maintain skin health and balance, and are involved in skin diseases and healing.
June 2023 in “Stem cell reviews and reports” Stem cell therapies could be a promising alternative for hair loss treatment, but more research is needed to understand their full potential and safety.
Different stem cells are key for hair growth and health, and understanding their regulation could help treat hair loss.
25 citations,
April 2021 in “The EMBO Journal” Hair follicle stem cells help maintain skin health and could improve skin replacement therapies.
