TREM2 Macrophages Induced by Human Lipids Drive Inflammation in Acne Lesions

    July 2022 in “ Science Immunology ”
    Tran Do, Feiyang Ma, Priscila Ribeiro Andrade … Robert L. Modlin
    Studysummary This study discovered that TREM2 macrophages influenced by squalene play a role in acne's development by hindering the killing of Cutibacterium acnes, helping explain why benzoyl peroxide is effective in treatment.
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    Research cited in this study 2

    1. Dietary Vitamin A Impacts Refractory Telogen Frontiers in Cell and Developmental Biology · 2021
    2. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth Cell Stem Cell · 2019