Understanding Type 3 Innate Lymphoid Cells and Crosstalk with the Microbiota: A Skin Connection

    February 2024 in “ International journal of molecular sciences ”
    Thao Tam To, Nicole Chizara Oparaugo, Alexander R. Kheshvadjian … George W. Agak
    Studysummary This study reviews current evidence on the role of ILC3s in the skin, highlighting their potential involvement in responding to microbiome changes such as those associated with acne and suggesting gaps in understanding their mechanisms.
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    Research cited in this study 12

    1. Distinct Mechanisms for Sebaceous Gland Self-Renewal and Regeneration Provide Durability in Response to Injury Cell Reports · 2023
    2. TREM2 Macrophages Induced by Human Lipids Drive Inflammation in Acne Lesions Science Immunology · 2022
    3. Immune Modulation of Hair Follicle Regeneration npj Regenerative Medicine · 2020
    4. The Dynamics of the Skin’s Immune System International Journal of Molecular Sciences · 2019
    5. Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium Cell · 2019
    6. Pten Loss In Lgr5+ Hair Follicle Stem Cells Promotes SCC Development Theranostics · 2019
    7. The Microbiome in Patients with Atopic Dermatitis Journal of Allergy and Clinical Immunology · 2018
    8. Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX3CR1- and TGF-β1-Dependent Manner Journal of Investigative Dermatology · 2018
    9. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    10. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    11. Epidermal Notch1 Recruits RORγ+ Group 3 Innate Lymphoid Cells to Orchestrate Normal Skin Repair Nature Communications · 2016
    12. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014