Understanding Type 3 Innate Lymphoid Cells and Crosstalk with the Microbiota: A Skin Connection

    February 2024 in “ International journal of molecular sciences ”
    Thao Tam To, Nicole Chizara Oparaugo, Alexander R. Kheshvadjian, Amanda M. Nelson, George W. Agak
    TLDR Type 3 Innate Lymphoid Cells help maintain skin health and balance, and are involved in skin diseases and healing.
    The document explores the role of Type 3 Innate Lymphoid Cells (ILC3s) in skin health and disease, emphasizing their interactions with the microbiota and various skin cells. ILC3s are crucial for maintaining skin homeostasis, microbial balance, and immune responses through cytokine production, such as IL-17 and IL-22. They are involved in inflammatory skin conditions like acne, psoriasis, atopic dermatitis, hidradenitis suppurativa, and cutaneous leishmaniasis, contributing to inflammation and immune regulation. Additionally, ILC3s play a role in wound healing and hair follicle regeneration. The study underscores the need for further research to understand the mechanisms of ILC3-microbiota crosstalk and its impact on skin diseases, which could lead to new therapeutic strategies.
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