Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium
February 2019
in “
Cell
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sebaceous glands innate lymphoid cells ILCs RORγt+ ILCs hair follicles IL-7 thymic stromal lymphopoietin chemokine receptor CCR6 TNF receptor ligands Notch signaling pathway sebocyte growth sebaceous hyperplasia antimicrobial lipid production Gram-positive bacterial communities immune-epithelia circuitry host-microbe symbiosis CCR6 TNF receptor Notch pathway antimicrobial lipids Gram-positive bacteria immune-epithelia host-microbe balance
TLDR Innate lymphoid cells help control skin bacteria by regulating sebaceous glands.
The study concluded that innate lymphoid cells (ILCs) played a crucial role in maintaining the homeostasis of sebaceous glands, which in turn regulated the equilibrium of commensal bacteria on the skin. ILCs influenced sebum production, essential for skin health and microbial balance. Disruption in this control could lead to skin disorders and imbalances in the skin microbiome. The research highlighted the importance of ILCs in skin health and their potential as therapeutic targets for skin-related conditions. The study used various experimental techniques and mouse models to demonstrate that ILCs regulate sebaceous gland function and lipid production, affecting the skin's microbial environment.
