Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium

    January 2019 in “ Cell ”
    Tetsuro Kobayashi, Benjamin Voisin, Do Young Kim, Elizabeth A. Kennedy, Jay‐Hyun Jo, Han‐Yu Shih, Amanda Truong, Thomas Döbel, Keiko Sakamoto, Chang‐Yi Cui, David Schlessinger, Kazuyo Moro, Susumu Nakae, Keisuke Horiuchi, Jinfang Zhu, Warren J. Leonard, Heidi H. Kong, Keisuke Nagao
    TLDR Innate lymphoid cells help control skin bacteria by regulating sebaceous glands.
    The study concluded that innate lymphoid cells (ILCs) played a crucial role in maintaining the homeostasis of sebaceous glands, which in turn regulated the equilibrium of commensal bacteria on the skin. ILCs influenced sebum production, essential for skin health and microbial balance. Disruption in this control could lead to skin disorders and imbalances in the skin microbiome. The research highlighted the importance of ILCs in skin health and their potential as therapeutic targets for skin-related conditions. The study used various experimental techniques and mouse models to demonstrate that ILCs regulate sebaceous gland function and lipid production, affecting the skin's microbial environment.
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