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Glossary Innate Lymphoid Cells

innate immune cells that respond quickly to infections and inflammation

Innate Lymphoid Cells (ILCs) are a group of immune cells that play a crucial role in the body's first line of defense against infections and in maintaining tissue homeostasis. Unlike adaptive immune cells, ILCs do not have antigen-specific receptors but can respond quickly to signals from damaged or infected tissues, helping to orchestrate the immune response and inflammation.

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research Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium

181 citations , January 2019 in “Cell”

In this research, authors found that skin-resident ILCs regulate sebaceous gland function and microbial balance, emphasizing an immune-epithelia system that supports host-microbe symbiosis.

research 937 Disruption of the innate lymphoid cell network alters the hair cycle during induced anagen

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that in immunodeficient mice lacking T cells, certain innate lymphoid cell subsets increased and influenced the hair growth cycle, with specific ILC subsets shown to promote anagen, the active phase of hair growth.

research Epidermal Notch1 recruits innate lymphoid cells to orchestrate normal skin repair

January 2014 in “Durham e-Theses (Durham University)”

In this study, the activation of Notch1 signaling in keratinocytes was found to play a key role in recruiting immune cells and facilitating skin repair after injury.

How Innate Lymphoid Cells Improved Our Understanding of Allergic Disease Mechanisms and Influenced Perspectives

research How the Innate Lymphoid Cells Improved Our Understanding of the Mechanisms of Allergic Diseases and Influenced the Standpoint?

January 2024 in “Asthma Allergy Immunology”

This review examines the role of innate lymphoid cells in allergic diseases and the influence of an allergic microenvironment on their plasticity, without reporting new clinical outcomes.

research 431 Innate lymphoid cells type 1 may be new, non-antigen-specific player in the pathogenesis of alopecia areata

September 2019 in “Journal of Investigative Dermatology”

This study suggests that in alopecia areata, innate lymphoid cells type 1 may contribute to the disease’s pathogenesis by inducing hair follicle changes similarly to CD8+ T cells.

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