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GlossaryLymphocytic Infiltration

accumulation of immune cells in tissue causing inflammation

Lymphocytic infiltration refers to the accumulation of lymphocytes, a type of white blood cell, in a particular tissue or organ. This often occurs as part of the body's immune response to infection, inflammation, or autoimmune conditions, where the immune system mistakenly attacks healthy cells. In the context of hair and alopecia, lymphocytic infiltration can be seen in conditions like alopecia areata, where the immune system targets hair follicles, leading to hair loss.

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research Werewolf, There Wolf: Variants in Hairless Associated with Hypotrichia and Roaning in the Lykoi Cat Breed

3 citations, May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The unique coat of lykoi cats is likely caused by new variants in the Hairless gene.

research Follicular Mycosis Fungoides: Variability of a Rare Entity

8 citations, January 2005 in “SKINmed Dermatology for the Clinician”

FMF and mycosis fungoides are variants of the same disease, and bexarotene can be an effective treatment.

research Propylthiouracil-Induced Alopecia Accompanying Hypohidrosis and Onychomadesis

August 2022 in “Acta dermato-venereologica”

Propylthiouracil can cause hair loss, reduced sweating, and nail issues, but stopping the drug can reverse hair and nail problems.

research Beard Involvement in a Man with Frontal Fibrosing Alopecia

14 citations, January 2014 in “Indian Journal of Dermatology Venereology and Leprology”

Frontal fibrosing alopecia can affect men's beards and leads to permanent hair loss.

research Clinical and Histopathological Features of Itch in Patients with Alopecia Areata

4 citations, January 2013 in “Acta dermato-venereologica”

Some patients with Alopecia Areata experience itch due to immune cells and enzymes that cause itching.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 6 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Dutasteride Isn't Working? Get a Scalp Biopsy NOW

in Finasteride/Dutasteride 19 upvotes 1 week ago

Dutasteride may not be effective for everyone due to underlying issues, suggesting scalp biopsies for further diagnosis. Users discuss using higher doses of dutasteride, topical treatments, minoxidil, and pyrilutamide for hair loss management.

community Lost density 60% all over scalp in 120 days (4months)

in Update 10 upvotes 8 months ago

A user lost 60% hair density in 4 months, started finasteride and microneedling, and has greasy, flaky, yellowish scalp. They are awaiting biopsy results, and another user suggested trying ketoconazole shampoo.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 5 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.