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GlossaryLymphocyte Infiltration

process where white blood cells accumulate in tissue

Lymphocyte infiltration refers to the process where lymphocytes, a type of white blood cell, move into and accumulate in a specific tissue or organ. This often occurs in response to infection, inflammation, or autoimmune conditions, where the immune system targets the body's own cells. In the context of alopecia, lymphocyte infiltration can lead to hair follicle damage, contributing to hair loss.

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research Alopecia Areata in C3H/HeJ Mice Involves Leukocyte-Mediated Root Sheath Disruption in Advance of Overt Hair Loss

37 citations, November 2003 in “Veterinary pathology”

Hair loss in mice starts with immune cells damaging hair roots before it becomes visible.

Pattern Hair Loss: Assessment of Microinflammation in Miniaturized and Terminal Hair Follicles Through Horizontal Histologic Sections

research Pattern Hair Loss: Assessment of Microinflammation in Miniaturized and Terminal Hair Follicles Through Horizontal Histologic Sections

11 citations, April 2020 in “Journal of The American Academy of Dermatology”

Microinflammation is more intense in smaller hair follicles and may be linked to hair loss.

research Alopecia Areata Universalis After Phenobarbital-Induced Anticonvulsant Hypersensitivity Syndrome

7 citations, January 2009 in “Immunological investigations”

A 3-year-old boy lost all his hair due to a rare reaction to phenobarbital, but it grew back after steroid treatment.

research Follicular Dysplasia and Hair Loss in White-Tailed Deer (Odocoileus Virginianus)

July 2023 in “Veterinary pathology”

White-tailed deer can get a hair loss condition that might make them more vulnerable to environmental threats.

research Alopecia Areata: Characteristics, Progression, and Associated Conditions

February 2023 in “Journal of vaccines and immunology”

Alopecia areata causes sudden hair loss, often on the scalp, and can be severe, especially with early onset or related health issues.

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community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 3 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Lost density 60% all over scalp in 120 days (4months)

in Update 10 upvotes 6 months ago

A user lost 60% hair density in 4 months, started finasteride and microneedling, and has greasy, flaky, yellowish scalp. They are awaiting biopsy results, and another user suggested trying ketoconazole shampoo.