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GlossaryNeutrophil Infiltration

movement of white blood cells into inflamed or infected tissue

Neutrophil infiltration refers to the process where neutrophils, a type of white blood cell, move from the bloodstream into a tissue where there is inflammation or infection. This is part of the body's immune response to help fight off pathogens or repair damaged tissue. For a professional, it indicates an acute inflammatory response, often seen in conditions like infections, autoimmune diseases, or tissue injury.

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research Overexpression of Protein Kinase C-α in the Epidermis of Transgenic Mice Results in Striking Alterations in Phorbol Ester-Induced Inflammation and COX-2, MIP-2, and TNF-α Expression but Not Tumor Promotion

135 citations , October 1999 in “Journal of Cell Science”

Overexpressing PKCα in mice skin increases inflammation but doesn't affect tumor growth.

research Nematic Fibrin Fibers Enabling Vascularized Thrombus Implants Facilitate Scarless Cutaneous Wound Healing

8 citations , April 2023 in “Advanced materials”

Using blood-based implants improves skin healing and reduces scarring.

research Inhibition of Glycosphingolipid Synthesis Reverses Skin Inflammation and Hair Loss in ApoE−/− Mice Fed Western Diet

30 citations , July 2018 in “Scientific Reports”

Blocking certain fat production can reverse skin inflammation and hair loss.

research Editor's Evaluation: Role of Distinct Fibroblast Lineages and Immune Cells in Dermal Repair Following UV Radiation-Induced Tissue Damage

June 2021

Different types of sun exposure damage skin cells and immune cells, with chronic exposure leading to more severe and lasting damage.

research Both Lesional and Non-Lesional Skin from Acne Patients Shows Robust IL-17-Skewing and Upregulation of Antimicrobial Peptides

April 2018 in “Journal of Investigative Dermatology”

Acne patients' skin, both with and without lesions, shows a strong immune response and higher antimicrobial activity.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community I got my bloodwork done... What now?

in Update 6 upvotes 2 months ago

The user has been experiencing hair thinning despite taking finasteride and minoxidil for six months. Bloodwork suggests a vitamin D deficiency, and users recommend consulting a doctor and possibly supplementing vitamin D.

community Hair is kinking rapidly following hair loss

in Update 1 upvotes 8 months ago

Hair loss has slowed, but uneven growth and kinking persist despite using keto/nizoral shampoo and clotrimazole. Stress and anxiety might be contributing factors.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 414 upvotes 11 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.