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GlossaryNeutrophil Extracellular Traps

web-like structures released by white blood cells to trap pathogens

Neutrophil Extracellular Traps (NETs) are web-like structures composed of DNA, histones, and antimicrobial proteins that are released by neutrophils, a type of white blood cell, to trap and kill pathogens. This process, known as NETosis, helps the immune system control infections but can also contribute to inflammation and tissue damage if not regulated properly.

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research Advances in Molecular Pathogenesis of Hidradenitis Suppurativa: Dysregulated Keratins and ECM Signaling

5 citations , February 2022 in “Seminars in cell & developmental biology”

Recent findings suggest that genetic factors, immune system issues, and skin cell defects might contribute to the development of hidradenitis suppurativa.

research Neutrophil Extracellular Traps Impair Regeneration

July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Neutrophil extracellular traps slow down hair follicle healing after injury.

research Neutralizing Alpha-Toxin Accelerates Healing of Staphylococcus Aureus-Infected Wounds in Normal and Diabetic Mice

April 2018 in “Journal of Investigative Dermatology”

Blocking α-toxin helps heal Staphylococcus aureus-infected wounds faster in both normal and diabetic mice, with different effects on their immune responses.

research Degradation of Aberrant NETs by DNases as a Therapeutic Strategy for SJS/TEN

April 2023 in “Journal of Investigative Dermatology”

Using DNase enzymes to break down harmful NETs could be a new treatment for Stevens-Johnson syndrome and toxic epidermal necrolysis.

research Targeting NETosis to Treat Delayed Wound Healing in a Humanized Mouse Model of Sickle Cell Disease

November 2024 in “Journal of Investigative Dermatology”

Reducing neutrophils or inhibiting NETs improves wound healing in sickle cell disease.

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community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 414 upvotes 11 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community I got my bloodwork done... What now?

in Update 6 upvotes 2 months ago

The user has been experiencing hair thinning despite taking finasteride and minoxidil for six months. Bloodwork suggests a vitamin D deficiency, and users recommend consulting a doctor and possibly supplementing vitamin D.

community Hair is kinking rapidly following hair loss

in Update 1 upvotes 8 months ago

Hair loss has slowed, but uneven growth and kinking persist despite using keto/nizoral shampoo and clotrimazole. Stress and anxiety might be contributing factors.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.