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GlossaryNeutrophil Extracellular Traps

web-like structures released by white blood cells to trap pathogens

Neutrophil Extracellular Traps (NETs) are web-like structures composed of DNA, histones, and antimicrobial proteins that are released by neutrophils, a type of white blood cell, to trap and kill pathogens. This process, known as NETosis, helps the immune system control infections but can also contribute to inflammation and tissue damage if not regulated properly.

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research Neutrophil Extracellular Traps Impair Regeneration

4 citations, October 2021 in “Journal of Cellular and Molecular Medicine”

White blood cells and their traps can slow down the process of new hair growth after a wound.

research Neutrophil Extracellular Traps Impair Regeneration

July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Neutrophil extracellular traps slow down hair follicle healing after injury.

research The Profibrogenic Role of Neutrophil Extracellular Traps in Stenotic Crohn's Disease: A New Antifibrotic Target?

May 2022 in “Gastroenterology”

Targeting NETs may help reduce fibrosis in Crohn's disease.

research Advances in Molecular Pathogenesis of Hidradenitis Suppurativa: Dysregulated Keratins and ECM Signaling

5 citations, February 2022 in “Seminars in cell & developmental biology”

Recent findings suggest that genetic factors, immune system issues, and skin cell defects might contribute to the development of hidradenitis suppurativa.

research Degradation of Aberrant NETs by DNases as a Therapeutic Strategy for SJS/TEN

April 2023 in “Journal of Investigative Dermatology”

Using DNase enzymes to break down harmful NETs could be a new treatment for Stevens-Johnson syndrome and toxic epidermal necrolysis.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.