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GlossaryNeutrophils

white blood cells that engulf and destroy pathogens

Neutrophils, also known as polymorphonuclear leukocytes (PMNs), are a type of white blood cell that plays a crucial role in the body's immune response. They are the first responders to sites of infection, where they engulf and destroy pathogens through a process called phagocytosis. Neutrophils are characterized by their multi-lobed nuclei and granular cytoplasm, which contains enzymes that help break down invading microbes.

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research Neutrophil Gelatinase-Associated Lipocalin Is a Marker for Dysregulated Keratinocyte Differentiation in Human Skin

96 citations, December 2002 in “Experimental dermatology”

NGAL indicates abnormal skin cell differentiation.

research Review of Aseptic Neutrophilic Dermatoses

17 citations, August 1983 in “Australasian Journal of Dermatology”

The review says skin conditions with sterile pustules need more research for better treatments.

Identifying Key Components and Therapeutic Targets of the Immune System in Hidradenitis Suppurativa with an Emphasis on Neutrophils

research Identifying Key Components and Therapeutic Targets of the Immune System in Hidradenitis Suppurativa with an Emphasis on Neutrophils

16 citations, September 2020 in “British journal of dermatology/British journal of dermatology, Supplement”

The article suggests that targeting specific immune pathways could help control and treat the skin disease hidradenitis suppurativa.

research Neutrophil Extracellular Traps Impair Regeneration

4 citations, October 2021 in “Journal of Cellular and Molecular Medicine”

White blood cells and their traps can slow down the process of new hair growth after a wound.

research Neutrophils Promote CXCR3-Dependent Itch in the Development of Atopic Dermatitis

1 citations, October 2019

Neutrophils are important for causing chronic itch in atopic dermatitis, and blocking the CXCR3 receptor may reduce this itch.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 6 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.