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GlossaryNeutrophils

white blood cells that engulf and destroy pathogens

Neutrophils, also known as polymorphonuclear leukocytes (PMNs), are a type of white blood cell that plays a crucial role in the body's immune response. They are the first responders to sites of infection, where they engulf and destroy pathogens through a process called phagocytosis. Neutrophils are characterized by their multi-lobed nuclei and granular cytoplasm, which contains enzymes that help break down invading microbes.

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Identifying Key Components and Therapeutic Targets of the Immune System in Hidradenitis Suppurativa with an Emphasis on Neutrophils

research Identifying Key Components and Therapeutic Targets of the Immune System in Hidradenitis Suppurativa with an Emphasis on Neutrophils

16 citations, September 2020 in “British journal of dermatology/British journal of dermatology, Supplement”

The article suggests that targeting specific immune pathways could help control and treat the skin disease hidradenitis suppurativa.

research Neutrophils Promote CXCR3-Dependent Itch in the Development of Atopic Dermatitis

1 citations, October 2019

Neutrophils are important for causing chronic itch in atopic dermatitis, and blocking the CXCR3 receptor may reduce this itch.

Targeting Anti-Inflammatory Immunonanocarriers to Human and Murine Neutrophils via Ly6 Antigen for Psoriasiform Dermatitis Alleviation

research Targeting Anti-Inflammatory Immunonanocarriers to Human and Murine Neutrophils via Ly6 Antigen for Psoriasiform Dermatitis Alleviation

April 2023 in “Journal of Investigative Dermatology”

The study created special nanoparticles that effectively deliver an anti-inflammatory drug to treat skin inflammation in psoriasis.

research Neutrophils Promote CXCR3-Dependent Itch in the Development of Atopic Dermatitis

July 2019

Neutrophils are key in causing chronic itch in atopic dermatitis, and blocking CXCR3 could reduce this itch.

research High-Fat Diet Exacerbates Neutrophilic Folliculitis by Facilitating Sequential Chemokine Expressions by Keratinocytes and Neutrophils

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

A high-fat diet worsens neutrophilic folliculitis by increasing certain chemokines.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 828 upvotes 5 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.