CXCL12+ Dermal Fibroblasts Promote Neutrophil Recruitment and Host Defense by Recognition of IL-17

January 2024 in “ The Journal of Experimental Medicine ”

Kellen Cavagnero, Fengwu Li, Tatsuya Dokoshi, Teruaki Nakatsuji, Alan M. O’Neill, Carlos Aguilera, Edward Liu, Michael A. Shia, Olive Osuoji, Tissa Hata, Richard L. Gallo

CXCL12 dermal fibroblasts neutrophil recruitment IL-17 TNFα CXCR2 ligands reticular dermis adipocyte lineage markers Il17ra psoriatic skin neutrophil chemotactic factors

Studysummary This study found that CXCL12+ fibroblast subsets in mouse skin play a critical role in recruiting neutrophils and defending against S. aureus infection, with similar fibroblast activity observed in human psoriatic skin. Our plain-language summary of this paper — not a Tressless recommendation.

The study explores the role of CXCL12+ dermal fibroblasts in neutrophil recruitment and host defense, particularly through IL-17 signaling, during Staphylococcus aureus infection. Using mouse models and human psoriasis samples, researchers found that these fibroblasts, especially those in the reticular and adipocyte lineages, are crucial for producing chemokines and antimicrobial factors in response to IL-17 and TNFα. This process, mediated by the transcriptional regulator NFKBIZ, enhances neutrophil migration and activation, which is vital for effective immune responses. The study highlights the potential for targeting IL-17 and TNFα pathways to improve treatments for skin diseases, emphasizing the critical and versatile role of CXCL12+ fibroblasts in amplifying inflammatory responses.

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Research cited in this study

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