Deep Skin Fibroblast-Mediated Macrophage Recruitment Supports Acute Wound Healing

August 2024

Veronica M. Amuso, MaryEllen R. Haas, Paula O. Cooper, Ranojoy Chatterjee, Sana Hafiz, Shatha Salameh, Chiraag Gohel, Miguel F. Mazumder, Violet Josephson, Khatereh Khorsandi, Anélia Horvath, Ali Rahnavard, Brett A. Shook

deep skin fibroblasts mesenchymal cells pro-inflammatory genes SCA1+ fibroblasts chemokines CCL2 CCL7 IL33 macrophages monocytes revascularization re-epithelialization

Studysummary In this study, researchers using single nuclei RNA-sequencing found that fibroblasts in deeper layers of mouse skin expressed higher levels of pro-inflammatory genes post-wounding compared to other cells, highlighting their significant role in early inflammation and tissue repair processes.

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