Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing
August 2020
in “
Cell stem cell
”
dermal fibroblasts wound healing hair follicle mesenchymal progenitors Hic1 reparative fibroblasts regeneration scar formation single-cell RNA-seq scATAC-seq transcriptional signatures regulatory signatures mesenchymal competence RUNX1 retinoic acid signaling fibroblasts wound repair hair follicle progenitors Hic1 gene healing fibroblasts scar tissue RNA sequencing regulatory genes mesenchymal cells RUNX1 gene vitamin A signaling
Studysummary In this study, researchers found that extrafollicular progenitors marked by Hic1 are the main contributors to reparative fibroblasts in wound repair, with potential to modulate healing outcomes through genetic and pharmacological interventions.
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