Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration

August 2018 in “ Cell Stem Cell ”

Zhou Yu, Kaiju Jiang, Zijian Xu, Huanwei Huang, Nannan Qian, Zhiwei Lu, Daoming Chen, Ruonan Di, Tianyi Yuan, Zhenhai Du, Wei Xie, Xiaoling Lu, Huawei Li, Renjie Chai, Yong Yang, Bing Zhu, Tetsuo Kunieda, FengChao Wang, Ting Chen

Hoxc genes Wnt signaling pathway mesenchymal niches hair follicle regeneration molecular mechanisms therapeutic intervention hair loss disorders

Studysummary This study found that Hoxc gene expression can reprogram mesenchymal dermal papilla cells, enhance epithelial stem cell regenerative potential, and promote region-specific hair follicle regeneration through Wnt signaling.

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This study found that Hoxc genes play a crucial role in regulating hair follicle regeneration through the Wnt signaling pathway. The expression of Hoxc genes in mesenchymal niches controls hair follicle regeneration through Wnt signaling, and Hoxc-dependent mesenchymal niche heterogeneity drives regional hair follicle regeneration. The study provides new insights into the molecular mechanisms underlying hair follicle regeneration and suggests potential targets for therapeutic intervention in hair loss disorders.

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research The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

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research In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators

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research The Mouse Hairy Ears Mutation Exhibits an Extended Growth (Anagen) Phase in Hair Follicles and Altered Hoxc Gene Expression in the Ears

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research A Position Effect on TRPS1 Is Associated with Ambras Syndrome in Humans and the Koala Phenotype in Mice

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