Fibroblasts: Origins, Definitions, and Functions in Health and Disease

    July 2021 in “ Cell ”
    Maksim V. Plikus, Xiaojie Wang, Sarthak Sinha, Elvira Forte, Sean Thompson, Erica L. Herzog, Ryan R. Driskell, Nadia Rosenthal, Jeff Biernaskie, Valerie Horsley
    TLDR Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.
    The document reviewed the origins, definitions, and functions of fibroblasts in health and disease, emphasizing their critical roles in tissue repair, fibrosis, and inflammatory responses. It discussed various signaling pathways, such as PDGF, TGF-beta, and BMP, that regulate fibroblast activity and differentiation. The review also highlighted the interactions between fibroblasts and other cell types, including inflammatory cells and adipocytes, and their contributions to conditions like skin fibrosis, lung fibrosis, and myocardial inflammation. Understanding fibroblast heterogeneity and the molecular mechanisms underlying their functions was emphasized as crucial for developing targeted therapies for fibrotic diseases.
    Discuss this study in the Community →

    Research cited in this study

    26 / 26 results

    Related Community Posts Join

    6 / 34 results

      community Comprehensive Microneedling Guide

      in Microneedling  295 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community I am actually regrowing my hairline without minoxidil or finasteride (mechanical stimulation)

       131 upvotes 7 years ago
      Regrowing hairline without the use of Minoxidil or Finasteride, and instead using mechanical stimulation such as Derma Roller, Nizoral, Zinc Pyrithione, Scalp Massage, Scalp Exercise, Fish Oil and other topical solutions. It is cautioned that there are risks associated with not using medically-prescribed treatments, but it is suggested to consider mechanical stimulation in addition to those prescribed treatments.

      community The Real Reason For Hair Loss?

      in Research/Science 2 weeks ago
      Hair loss is linked to scalp fibrosis and tension, which result from chronic mechanical stress and androgenic signaling. Treatments include blocking androgens with finasteride, promoting hair growth with topical minoxidil, and improving scalp mobility through exercises.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  734 upvotes 3 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community Summary of Procapil video by Haircafe

      in Minoxidil  2 upvotes 6 months ago
      Procapil is marketed as a natural hair loss treatment but lacks strong evidence and is industry-biased. Minoxidil and Finasteride are the only FDA-approved treatments for androgenetic alopecia.

    Similar Research

    5 / 1000+ results