Fibroblasts in Diabetic Foot Ulcers

    February 2024 in “ International Journal of Molecular Sciences ”
    Francesca Voza, Carlos Theodore Huerta, Nga Le, Hongwei Shao, Antoine J. Ribieras, Yulexi Y. Ortiz, Carl Atkinson, Tiago Machuca, Zhao‐Jun Liu, Omaida C. Velázquez
    Studysummary This study highlights the crucial, multifaceted roles of fibroblasts in wound healing and various diseases, including their dysregulation in diabetic foot ulcers, underscoring the need for targeted therapies to address complications and morbidity from such chronic conditions. Our plain-language summary of this paper — not a Tressless recommendation.
    The document reviews the critical role of fibroblasts in diabetic foot ulcers (DFUs), highlighting their dynamic functions in tissue homeostasis and wound healing. Fibroblasts, once considered passive, are now recognized for their ability to switch phenotypes and regulate processes like angiogenesis and inflammation. Dysregulation of fibroblasts due to hyperglycemia and metabolic memory leads to impaired wound healing, characterized by chronic inflammation and poor transition from the inflammatory to the proliferative phase. The review emphasizes the need for innovative treatments, as current therapies often fail, leading to high risks of limb amputation. Understanding fibroblast heterogeneity and signaling pathways, such as TGF-β and Notch, could aid in developing novel therapeutics for chronic wound healing in diabetic patients.
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