Fibroblasts in Diabetic Foot Ulcers

Fibroblasts, once thought to be passive cells, are now recognized for their dynamic role in tissue homeostasis and wound healing, particularly in diabetic foot ulcers (DFUs), which affect 40 to 60 million people. These cells are crucial in regulating angiogenesis and inflammation, and their dysregulation is linked to chronic conditions like diabetes mellitus. DFUs, a severe complication of diabetes, lead to significant health risks such as infections and amputations. Understanding fibroblast dysregulation in DFUs is essential for developing new treatments to improve patient outcomes.