Fibroblasts: Immunomodulatory Factors in Refractory Diabetic Wound Healing

August 2022 in “ Frontiers in Immunology ”

Ye Liu, Yiqiu Liu, Wenjie He, Xingrui Mu, Xingqian Wu, Junyu Deng, Xuqiang Nie

fibroblasts chronic diabetic wounds extracellular matrix immune response high glucose levels hepatocyte growth factors fibroblast dysfunction oxidative stress myofibroblasts tissue remodeling inflammation myofibroblast differentiation

TLDR Fibroblasts are important in healing diabetic wounds, but high sugar levels can harm their function and slow down the healing process.

The document "Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing" discusses the role of fibroblasts in the healing of chronic diabetic wounds. Fibroblasts, previously considered "immune neutral" cells, are now recognized as critical in the wound healing process, as they construct and reshape the extracellular matrix and regulate the immune response. The study found that high glucose levels negatively affect the proliferation and migration of hepatocyte growth factors, leading to fibroblast dysfunction and delayed wound healing. Oxidative stress in a high glucose environment is identified as the cause of this dysfunction. The study also found a significant reduction in myofibroblasts in diabetic rats compared to non-diabetic rats, which is associated with decreased tissue remodeling, increased inflammation, and delayed myofibroblast differentiation. The document suggests that further research on fibroblasts could help restore homeostasis in diabetic wound healing.

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