Gene Therapy to Enhance Angiogenesis in Chronic Wounds
August 2022
in “
Molecular Therapy — Nucleic Acids
”
gene therapy angiogenesis chronic wounds diabetic models gene delivery electroporation liposomal carriers biodegradable nanoparticles VEGF TGF-β1 HIF-1α re-epithelialization collagen synthesis neovascularization non-viral delivery systems RNA interference CRISPR/Cas9 vascular endothelial growth factor transforming growth factor beta 1 hypoxia-inducible factor 1-alpha
TLDR Gene therapy shows promise for healing chronic wounds but needs more research to overcome challenges.
The document reviews various gene therapy strategies aimed at enhancing angiogenesis to improve healing in chronic wounds, particularly in diabetic models. It discusses the use of gene delivery methods such as electroporation, liposomal carriers, and biodegradable nanoparticles to introduce genes like VEGF, TGF-β1, and HIF-1α into animal models, resulting in increased re-epithelialization, collagen synthesis, and neovascularization. The review highlights the potential of non-viral delivery systems and innovative techniques like RNA interference and CRISPR/Cas9 to regulate angiogenesis and accelerate wound healing. Despite promising results, challenges such as delivery method limitations and production costs remain, necessitating further research to optimize these therapies for clinical application.
