Epidermal Stem Cells Manipulated by pDNA-VEGF165/CYD-PEI Nanoparticles Loaded Gelatin/β-TCP Matrix as a Therapeutic Agent and Gene Delivery Vehicle for Wound Healing
June 2013
in “
Molecular Pharmaceutics
”
epidermal stem cells VEGF165 CYD-PEI gelatin/β-TCP scaffold nanoparticles wound healing transfection dermal collagen synthesis hair follicle regeneration angiogenesis scar inhibition ESCs vascular endothelial growth factor polyethylenimine gelatin scaffold gene delivery collagen synthesis hair regeneration blood vessel formation scar reduction
Studysummary This study demonstrates that transfected epidermal stem cells using a novel 3D transfection system significantly enhanced wound healing and may serve as an effective therapeutic agent and gene delivery method for wound treatment.
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