Exploring the Role of Stem Cells in Cutaneous Wound Healing

November 2009 in “ Experimental Dermatology ”

Katherine Lau, Ralf Paus, Stephan Tiede, Philip J. Day, Ardeshir Bayat

TLDR Stem cells are crucial for wound healing and understanding their role could lead to new treatments, but more research is needed to answer unresolved questions.

The 2009 review "Exploring the role of stem cells in cutaneous wound healing" discussed the crucial role of adult stem cells (ASCs) in tissue regeneration and wound healing. The paper highlighted the importance of understanding the contribution of ASCs to normal and impaired wound healing for better control of wound repair and the development of novel treatment strategies. It identified various types of stem cells involved in cutaneous repair, including bone marrow-derived cells, tissue-resident endothelial precursors, pluripotent nestin expressing cells, and hair follicle mesenchymal stem cells. The study also emphasized the significant role of hair follicles as a local reservoir for various progenitor cell populations that play key roles in wound healing. The document concluded that further research into the role of stem cells in cutaneous healing could lead to new therapies for managing difficult wounds. However, it also noted that many unresolved questions regarding the experimental and clinical application of stem cells in wound healing need to be systematically addressed in future research.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Cited in this study

11 / 11 results

research Human Skin Stem Cells and the Aging Process

143 citations , November 2008 in “Experimental gerontology”

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

835 citations , October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

research An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution

170 citations , May 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.

research Hair Follicle Stem Cells: Walking the Maze

165 citations , July 2007 in “European Journal of Cell Biology”

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Hair Follicles and Their Role in Skin Health

16 citations , December 2006 in “Expert Review of Dermatology”

Hair follicles are essential for skin health, aiding in hair growth, wound healing, and immune function.

research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

550 citations , December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.

research Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

87 citations , March 2004 in “Plastic and Reconstructive Surgery”

Hair follicle stem cells helped heal a severe scalp burn without needing traditional skin grafts.

research Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme During the Hair Growth Cycle: Implications for Growth Control and Hair Follicle Transformations

54 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Disruptions in hair follicle fibroblast dynamics can cause hair growth problems.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations , January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

2 / 2 results

research Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications

232 citations , October 2015 in “International journal of molecular sciences”

Stem cells are crucial for skin repair and new treatments for chronic wounds.

research Exploring the Role of Stem Cells in Cutaneous Wound Healing

222 citations , November 2009 in “Experimental Dermatology”

Stem cells are crucial for wound healing and understanding their role could lead to new treatments, but more research is needed to answer unresolved questions.