Exploring the Role of Stem Cells in Cutaneous Wound Healing

August 2009 in “ Experimental Dermatology ”

Katherine Lau, Ralf Paus, Stephan Tiede, Philip J. Day, Ardeshir Bayat

adult stem cells tissue regeneration wound healing bone marrow-derived cells tissue-resident endothelial precursors pluripotent nestin expressing cells hair follicle mesenchymal stem cells hair follicles progenitor cell populations ASCs stem cells endothelial precursors nestin cells hair follicle stem cells

TLDR Stem cells are crucial for wound healing and understanding their role could lead to new treatments, but more research is needed to answer unresolved questions.

The 2009 review "Exploring the role of stem cells in cutaneous wound healing" discussed the crucial role of adult stem cells (ASCs) in tissue regeneration and wound healing. The paper highlighted the importance of understanding the contribution of ASCs to normal and impaired wound healing for better control of wound repair and the development of novel treatment strategies. It identified various types of stem cells involved in cutaneous repair, including bone marrow-derived cells, tissue-resident endothelial precursors, pluripotent nestin expressing cells, and hair follicle mesenchymal stem cells. The study also emphasized the significant role of hair follicles as a local reservoir for various progenitor cell populations that play key roles in wound healing. The document concluded that further research into the role of stem cells in cutaneous healing could lead to new therapies for managing difficult wounds. However, it also noted that many unresolved questions regarding the experimental and clinical application of stem cells in wound healing need to be systematically addressed in future research.

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