Multifunctional Self-Assembled Peptide Hydrogels for Biomedical Applications

    February 2023 in “ Polymers ”
    Mahsa Sedighi, Neha Shrestha, Zahra Mahmoudi, Zahra Khademi, Alireza Ghasempour, Hamideh Dehghan, Seyedeh Fahimeh Talebi, Maryam Toolabi, Véronique Préat, Bo Zhi Chen, Xindong Guo, Mohammad‐Ali Shahbazi
    Studysummary This review discusses the unique properties, design, and fabrication of peptide hydrogels for biomedical applications, focusing on advances in drug delivery, gene therapy, and regenerative medicine; it reports no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.
    The document reviews the potential of multifunctional self-assembled peptide hydrogels in various biomedical applications due to their bioactivity, biocompatibility, and biodegradability. These hydrogels can mimic natural tissue environments and respond to stimuli for controlled drug release, making them suitable for regenerative medicine, drug delivery, tissue engineering, and wound healing. They are formed through various intra-peptide interactions, allowing for diverse structures and applications, including targeted drug and gene delivery, stem cell therapy, cancer therapy, immune regulation, bioimaging, and regenerative medicine. Despite their advantages, further research is needed to address challenges such as clinical translation and physiological relevance.
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