Self-Assembling Peptide Hydrogel Scaffolds Support Stem Cell-Based Hair Follicle Regeneration

June 2016 in “ Nanomedicine: Nanotechnology, Biology and Medicine ”

Xiaoxiao Wang, Jin-Mei Wang, Ling Guo, Xusheng Wang, Haiyan Chen, Xiumei Wang, Jianjun Liu, Edward E. Tredget, Yaojiong Wu

self-assembling peptide hydrogel scaffolds stem cell-based hair follicle regeneration skin-derived precursor cells SKPs RADA16 PRG tissue engineering peptide hydrogel stem cell hair regeneration skin precursor cells

TLDR Peptide hydrogel scaffolds help grow new hair follicles using stem cells.

This study from 2016 investigated the use of self-assembling peptide hydrogel scaffolds to support stem cell-based hair follicle regeneration. The researchers found that the hydrogels were effective in promoting the growth and differentiation of skin-derived precursor cells (SKPs) into hair follicles, with the RADA16 and PRG mixture being particularly effective. The study suggests that self-assembling peptide hydrogel scaffolds have potential for use in hair follicle regeneration and tissue engineering.

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Research cited in this study

6 / 6 results

research Emerging Interactions Between Skin Stem Cells and Their Niches

426 citations, August 2014 in “Nature Medicine”

Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.

research Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach

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The document concludes that dermal papilla cells are key for hair growth and could be used in new hair loss treatments.

research Dynamic Signals for Hair Follicle Development and Regeneration

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research SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells

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SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.

research Hair Follicle Neogenesis Induced by Cultured Human Scalp Dermal Papilla Cells

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research Scratching the Surface of Skin Development

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research Hair Follicle Stem Cells as a Skin-Organizing Signaling Center During Adult Homeostasis

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research New Substrates for Stem Cell Control

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Self-Assembling Peptide Hydrogel Scaffolds Support Stem Cell-Based Hair Follicle Regeneration

Research cited in this study

research Emerging Interactions Between Skin Stem Cells and Their Niches

research Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach

research Dynamic Signals for Hair Follicle Development and Regeneration

research SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells

research Hair Follicle Neogenesis Induced by Cultured Human Scalp Dermal Papilla Cells

research Scratching the Surface of Skin Development

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