Release Systems Based on Self-Assembling RADA16-I Hydrogels With a Signal Sequence Which Improves Wound Healing Processes

The study investigates self-assembling RADA16-I hydrogels functionalized with bioactive peptides (GHK, KGHK, and RDKVYR) to enhance wound healing. These hydrogels form stable β-sheet structures, support cell attachment and proliferation, and facilitate controlled release of therapeutic molecules. In vitro tests with human dermal fibroblasts and in vivo experiments on mice showed significant improvements in wound healing, including faster wound closure, increased collagen density, and enhanced tissue regeneration. The hydrogels were non-cytotoxic and promoted angiogenesis, immune cell attraction, and fibroblast proliferation, making them promising candidates for advanced wound healing applications.