Release Systems Based on Self-Assembling RADA16-I Hydrogels With a Signal Sequence Which Improves Wound Healing Processes

April 2023 in “ Scientific Reports ”

Maria Dzierżyńska, Justyna Sawicka, Milena Deptuła, Paweł Sosnowski, Piotr Sass, Barbara Peplińska, Zuzanna Pietralik-Molińska, Martyna Fularczyk, Franciszek Kasprzykowski, Jacek Zieliński, Maciej Kozak, Paweł Sachadyn, Michał Pikuła, Sylwia Rodziewicz-Motowidło

RADA16-I hydrogels bioactive peptides GHK KGHK RDKVYR β-sheet structures human dermal fibroblasts collagen density tissue regeneration angiogenesis immune cell attraction fibroblast proliferation collagen fibroblasts

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Studysummary This study reported that newly developed RADA16-I peptide hybrids, with active motifs like GHK and KGHK, demonstrated improved wound healing in a mouse skin injury model without cytotoxicity, suggesting they might be effective scaffolds for tissue engineering and regeneration.

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research Design of a RADA16-Based Self-Assembling Peptide Nanofiber Scaffold for Biomedical Applications

39 citations , April 2019 in “Journal of Biomaterials Science, Polymer Edition”

This review discusses recent research and applications of RADA16 and RADA16-based peptide scaffolds in biomedicine, including their roles in tissue repair and drug delivery, but reports no new clinical results.

research Engineering Pro-Regenerative Hydrogels for Scarless Wound Healing

55 citations , April 2018 in “Advanced Healthcare Materials”

This review discusses recent advances in scarless wound healing, focusing on strategies to create pro-regenerative scaffolds for repairing damaged skin, and reports no new clinical results.

research Self-Assembling Peptide Hydrogel Scaffolds Support Stem Cell-Based Hair Follicle Regeneration

38 citations , June 2016 in “Nanomedicine: Nanotechnology, Biology and Medicine”

In this study, the RADA-PRG hydrogel enhanced SKP proliferation, survival, and gene expression, effectively supporting hair follicle regeneration in mice.

research Cutaneous Wound Healing: Recruiting Developmental Pathways for Regeneration

471 citations , October 2012 in “Cellular and Molecular Life Sciences”

This review discusses the roles of key developmental signaling pathways in mammalian skin repair compared to skin development, and suggests these insights could lead to better wound healing therapies, but it reports no new findings.

research Dextran Hydrogel Scaffolds Enhance Angiogenic Responses and Promote Complete Skin Regeneration During Burn Wound Healing

527 citations , December 2011 in “Proceedings of the National Academy of Sciences”

This study found that dextran-based hydrogels promoted significant neovascularization and skin regeneration in mouse models of third-degree burns, without the need for additional growth factors or cells.

research The Human Tri-Peptide GHK and Tissue Remodeling

165 citations , January 2008 in “Journal of biomaterials science. Polymer ed.”

This review outlines the various processes activated by the peptide GHK-Cu in tissue remodeling and reports improvements in skin and wound healing but notes a need for further study to fully understand these mechanisms.