Study of the Interaction Between Self-Assembling Peptide and Mangiferin and In Vitro Release of Mangiferin From In Situ Hydrogel

    September 2019 in “ International Journal of Nanomedicine ”
    Meng Cui, Weipeng Wei, Yuhe Wang, Kunqin Zhang, Ting Zhang, Yunyan Tang, Fushan Tang
    TLDR RADA16-I can effectively deliver and release mangiferin, improving its solubility and bioavailability.
    The study explored the potential of the self-assembling peptide RADA16-I as a drug delivery carrier for the hydrophobic compound mangiferin (MA). It demonstrated that RADA16-I could significantly enhance the solubility of MA by forming a colloidal suspension and effectively encapsulate and release MA from hydrogels. The RADA16-I–MA hydrogels showed improved antitumor effects and reduced toxicity to normal cells due to their slow and sustained release properties. The study concluded that RADA16-I could serve as a promising carrier for hydrophobic drugs, offering a stable injectable drug carrier or hydrogel matrix for therapeutic applications, although further in vivo studies and cost considerations were necessary for practical use.
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