Effective Treatment of Intractable Diseases Using Nanoparticles to Interfere with Vascular Supply and Angiogenic Process

The document discussed the use of nanoparticles (NPs) in treating various intractable diseases by interfering with vascular supply and angiogenesis. NPs were shown to enhance or suppress angiogenesis, offering potential treatments for conditions like cancer, diabetic retinopathy, ischemic stroke, and peripheral artery disease. The research highlighted the use of NPs for improved drug delivery, targeting, and minimizing side effects. Various studies demonstrated the effectiveness of NPs in promoting angiogenesis, reducing infarct size, and improving therapeutic outcomes in animal models. Despite promising preclinical results, challenges such as nanotoxicity, inefficient gene transfection, and the need for large-scale human trials were noted. The document emphasized the potential of NPs in developing innovative therapeutic strategies by modulating angiogenesis and improving drug delivery.