Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications

    August 2020 in “ Nanomaterials ”
    Simin Nazarnezhad, Francesco Baino, Hae‐Won Kim, Thomas J Webster, Saeid Kargozar
    Image of study
    TLDR Electrospun nanofibers show promise for enhancing blood vessel growth in tissue engineering but need further research to improve their effectiveness.
    The document reviews the use of electrospun nanofibers in tissue engineering, emphasizing their potential to enhance angiogenesis, which is essential for tissue repair and regeneration. It details how the properties of nanofibers, such as their ECM-mimicking structure and high surface area, can be tailored to improve angiogenesis by incorporating bioactive components, stem cells, and growth factors like VEGF. The review discusses various strategies, including the use of natural and synthetic polymers, surface functionalization, and the controlled release of pro-angiogenic molecules to induce vessel formation. It also considers the role of inorganic elements and bioceramics in promoting angiogenesis while addressing cytotoxicity concerns. The document reports on studies that have shown the effectiveness of these scaffolds in bone and skin regeneration, as well as the potential for neuroregeneration. However, it concludes that more research is needed to overcome limitations such as limited cell infiltration and to optimize the scaffolds' physical and chemical properties for repairing highly vascularized tissues and organs.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 50 results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  41 upvotes 6 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community BPC-157 and Angiogenesis. Bro-Science-Execution-Plan

      in Research/Science  13 upvotes 8 months ago
      BPC-157 may promote hair growth by increasing angiogenesis, similar to how Minoxidil works, though no direct research confirms this yet. Users report combining BPC-157 with Minoxidil and finasteride for better results, but concerns about long-term safety exist.

      community Debunking Androgenetic Theory (Hair Transplants)

      in Research/Science  25 upvotes 2 years ago
      The post discusses a theory that hair regrowth after transplant is due to the angiogenesis process (new blood vessels forming), not because the transplanted hair is unaffected by DHT. The responses highlight the established belief in 'donor dominance' (the importance of the hair's origin in transplantation) and skepticism about the new theory.

      community Deoxyribose sugar gel worked just as well as minoxidil

      in Research/Science  17 upvotes 1 year ago
      A deoxyribose sugar gel may work as well as minoxidil for hair regrowth by boosting blood supply to hair follicles. Some users discuss combining it with minoxidil and cetrizine, but caution is advised due to potential risks and lack of consistent results.

      community Comprehensive Microneedling Guide

      in Microneedling  292 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

    Similar Research

    5 / 1000+ results