Recent Advances in Glycopeptide Hydrogels: Design, Biological Functions, and Biomedical Applications

Glycopeptide hydrogels are advanced biomaterials that replicate the extracellular matrix's structure and functions, offering significant potential in biomedical applications such as tissue regeneration, wound healing, drug delivery, and antimicrobial therapies. This review explores the design principles and multifunctional properties of these hydrogels, including their antimicrobial, immunomodulatory, and antioxidant activities, as well as their ability to adhere to tissues and promote angiogenesis. The review also assesses their applications in regenerative medicine, particularly for wound healing, bone and cartilage reconstruction, myocardial repair, and neural regeneration. Future advancements are suggested, focusing on expanding bioactive motifs, enhancing biomechanical mimicry, and simulating organ-specific environments for precision medicine.