Engineering Cell-Derived Matrices: From 3D Models to Advanced Personalized Therapies

The document reviewed the advancements in regenerative medicine and disease models, highlighting the shift from 2D to 3D constructs that better mimic in vivo tissues. It focused on cell-derived matrices (CDMs) as modifiable extracellular matrices for various tissues, enabling the study of cellular processes, tissue regeneration, and disease modeling. The review covered different fabrication techniques and characterization methods of CDMs, provided examples of their applications, and discussed future guidelines and perspectives in the field.