Novel Skin Patch Combining Human Fibroblast-Derived Matrix and Ciprofloxacin for Infected Wound Healing

January 2018 in “ Theranostics ”

Muhammad Suhaeri, Mi Hee Noh, Ji-Hoi Moon, In Gul Kim, Se H. Oh, Sang Su Ha, Jong Ho Lee, Kwideok Park

human fibroblast-derived matrix ciprofloxacin polyvinyl alcohol hydrogel wound healing re-epithelialization collagen texture skin regeneration extracellular matrix antibacterial activity hFDM Cipro PVA hydrogel ECM

TLDR The new skin patch with human matrix and antibiotic improves wound healing.

In the 2018 study, researchers developed a novel skin patch that combined a human fibroblast-derived matrix (hFDM) with the antibiotic ciprofloxacin (Cipro) in a polyvinyl alcohol (PVA) hydrogel for the treatment of infected wounds. The patch was tested in vitro and found to be non-cytotoxic, supported cell attachment and migration, and exhibited strong antibacterial activity against both gram-negative and gram-positive bacteria. An animal study using BALB/c mice with infected wounds showed that the PVA/Cipro/hFDM patch significantly improved wound healing over 21 days, with advanced skin regeneration including re-epithelialization, improved collagen texture and distribution, and regeneration of skin adnexa. The study concluded that the skin patch effectively combined the regenerative potential of ECM with the antibacterial activity of Cipro, leading to enhanced wound healing.

View this study on thno.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 852 results

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 101 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 74 upvotes 5 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community This serum outperformed Minoxidil in a recent study. Please debunk

23 upvotes 5 years ago

A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

community Verteporfin and Microneedling

in Treatments 6 months ago

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

community Comprehensive Microneedling Guide

in Microneedling 290 upvotes 2 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community So does oral minoxidil age your skin or not

in Minoxidil 41 upvotes 8 months ago

Oral minoxidil may cause dry skin and dark eye bags but doesn't significantly age the skin. Topical minoxidil is toxic to cats, and some users prefer finasteride.

Related Research

1 / 1 results

research Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling

8 citations, June 2022 in “Frontiers in bioengineering and biotechnology”

A patch made from human lung fibroblast material helps heal skin wounds effectively, including diabetic ulcers.