Biomimetic Scaffolds: A Novel Approach to Three-Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

    March 2024 in “ Nanomaterials ”
    Tomasz Górnicki, Jakub Lambrinow, Afsaneh Golkar‐Narenji, Krzysztof Data, Dominika Domagała, Julia Niebora, Maryam Farzaneh, Paul Mozdziak, Maciej Zabel, Paweł Antosik, Dorota Bukowska, K. Ratajczak, Marzenna Podhorska‐Okołów, Piotr Dzięgiel, Bartosz Kempisty
    Studysummary This review article summarizes recent advancements in biomimetic scaffolds, highlighting their promise in tissue engineering and personalized medicine, particularly for skin and musculoskeletal system regeneration, while emphasizing the need for more extensive research to ensure their safety for human use.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The article reviews advancements in biomimetic scaffolds for three-dimensional (3D) cell culture techniques, emphasizing their superiority over traditional two-dimensional (2D) cultures in mimicking natural tissue environments. These scaffolds, made from materials like hydrogels and decellularized extracellular matrix (dECM), support cell adhesion, proliferation, and differentiation, crucial for tissue regeneration. The review highlights the potential of these scaffolds in regenerating various tissues, including skin, musculoskeletal, endocrine, and genitourinary systems, and underscores the need for further research to ensure their safety and efficacy in clinical applications. Advanced 3D bioprinting techniques, including 4D bioprinting, are also discussed for their role in creating dynamic, responsive biomaterials for tissue engineering and regenerative medicine.
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