Integrating Zinc/Silicon Dual Ions With 3D-Printed GelMA Hydrogel Promotes In Situ Hair Follicle Regeneration

    March 2023 in “ International Journal of bioprinting ”
    Fanliang Zhang, Zhaowenbin Zhang, Xianlan Duan, Wei Song, Zhao Li, Bin Yao, Yi Kong, Xing Huang, Xiaobing Fu, Jiang Chang, Sha Huang
    TLDR Zinc/silicon-infused hydrogel helps regenerate hair follicles.
    The study investigates the use of a 3D-printed GelMA hydrogel scaffold infused with zinc and silicon ions to promote hair follicle regeneration. Results show that this GelMA-zinc/silicon hydrogel activates hair follicle stem cells and enhances neovascularization, leading to hair growth and improved perfusion recovery in a mouse excisional model. This approach effectively regulates hair follicle regeneration by impacting stem cells and promoting angiogenesis, presenting a promising strategy for cutaneous regenerative medicine.
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