Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review
July 2018
in “
Antioxidants
”
Studysummary This review discusses the role of reactive oxygen species in wound healing, highlighting potential strategies like mitochondrial-targeted antioxidants for managing non-healing chronic wounds, and reports no new clinical results.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The 2018 systematic review examined the impact of oxidative stress and mitochondrial dysfunction on impaired wound healing, with a particular focus on chronic wounds such as those associated with diabetes. It found that while reactive oxygen species (ROS) are necessary for normal healing processes, their overproduction or insufficient removal can cause oxidative damage and lead to non-healing wounds. The review highlighted the potential of antioxidants and anti-inflammatory treatments that target mitochondrial dysfunction, such as elamipretide, to improve wound healing. It also discussed the role of advanced glycation end products (AGEs) in diabetic wounds, which contribute to oxidative damage and impaired healing. The review concluded that redox-based therapeutic strategies, especially those targeting mitochondrial ROS, show promise in treating chronic wounds and should be further developed and evaluated in clinical settings.
