The Therapeutic Role of ADSC-EVs in Skin Regeneration

June 2022 in “ Frontiers in Medicine ”

Yixi Wang, Lin Cao, Hanxing Zhao, Zhengyong Li, Junjie Chen, Ying Cen, Zhenyu Zhang

TLDR ADSC-derived extracellular vesicles show promise for skin and hair regeneration and wound healing.

Extracellular vesicles (EVs) derived from adipose-derived stem cells (ADSCs) have shown potential in skin regeneration, wound healing, and hair regeneration. They participate in inflammation, angiogenesis, cell proliferation, and extracellular matrix remodeling, which are crucial processes in wound healing. They also promote skin barrier repair and have been used in the treatment of diabetic ulcers and other skin diseases. Methods for isolating these EVs include microfluidic techniques, bioreactor culture of parental cells, and hydrostatic filtration dialysis. Despite promising findings, more research is needed to understand the specific mechanisms of ADSC-EVs' regenerative function and to overcome challenges in their manufacture and application.

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