Mesothelial Stem Cells and Stromal Vascular Fraction for Skin Rejuvenation

August 2018 in “ Facial Plastic Surgery Clinics of North America ”

David Wolf, William H. Beeson, John D. Rachel, Gregory S. Keller, C. William Hanke, Jill Waibel, Matt Leavitt, Michael Sacopulos

adipose-derived stem cells stromal vascular fraction skin rejuvenation hair restoration wound healing growth factors collagen synthesis anti-aging effects neovascularization tissue engineering ASCs SVF

Studysummary This study reviewed the prospects and challenges of using stem cells from adipose tissue in regenerative medicine for facial rejuvenation, emphasizing the need for further research to ensure patient safety before these methods can become routine in cosmetic and reconstructive surgery.

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The document from November 1, 2018, explores the potential of adipose-derived stem cells (ASCs) and stromal vascular fraction (SVF) in skin rejuvenation, hair restoration, and wound healing. It discusses the role of ASCs in producing growth factors that aid skin homeostasis and repair, and their ability to differentiate into various cell lineages, accelerate wound closure, and promote collagen synthesis. Clinical studies have shown ASCs can mediate anti-aging effects and improve wound healing, but more research is needed to fully understand their mechanisms and optimize their use. The document also addresses the regulatory environment for stem cell therapies, highlighting FDA concerns and the need for further research on ASC purity, molecular phenotype, and potential cancer relationships. It concludes that while ASCs show promise in regenerative medicine, challenges remain in terms of cell expansion, neovascularization, and scaffold development for tissue engineering.

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Research cited in this study

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research Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging

132 citations , January 2017 in “International Journal of Molecular Sciences”

This review explores how adipose-derived stem cells contribute to skin homeostasis and highlights recent advances in their clinical applications in dermatology, but it reports no new clinical results.

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research Hair Follicle-Derived IL-7 and IL-15 Mediate Skin-Resident Memory T Cell Homeostasis and Lymphoma

245 citations , October 2015 in “Nature medicine”

The research found that hair follicle–derived cytokines, particularly IL-15 and IL-7, regulate skin-resident memory T cells and their role in both immune homeostasis and lymphoma in the skin.

research Intradermal Adipocytes Mediate Fibroblast Recruitment During Skin Wound Healing

238 citations , March 2013 in “Development”

This study found that adipocytes play a crucial role in skin wound healing by facilitating fibroblast recruitment and dermal reconstruction during the healing process.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations , February 2009 in “Nature Reviews Molecular Cell Biology”

This review discusses the reuse of molecular mechanisms involved in embryonic skin development for maintaining adult epidermal homeostasis and reports no new results.

research Probing the Effects of Stress Mediators on the Human Hair Follicle

159 citations , November 2007 in “American Journal of Pathology”

In this study, researchers found that substance P triggered premature catagen development and immune changes in human scalp hair follicles, providing a possible biological link between stress and hair loss conditions like telogen effluvium and alopecia areata.