Mechanical Fractionation of Adipose Tissue: A Scoping Review of Procedures to Obtain Stromal Vascular Fraction

October 2023 in “ Bioengineering ”

J. Schipper, Constance van Laarhoven, Rutger H. Schepers, Ashley M. Tuin, Martin C. Harmsen, Fred K. L. Spijkervet, J. Jansma, Joris A. van Dongen

stromal vascular fraction adipose tissue mechanical fractionation centrifugation filtration regenerative medicine

Studysummary This study reviewed the efficacy of mechanical fractionation techniques to produce tissue stromal vascular fraction (tSVF) and found that tSVF injections are particularly effective for conditions like osteoarthritis and wound healing, with centrifugation before fractionation improving isolation efficiency regardless of preparation method.

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This scoping review evaluates mechanical fractionation methods for obtaining stromal vascular fraction (tSVF) from adipose tissue, used in regenerative therapies. It includes data from 1,465 patients and 410 animals, finding that tSVF is more effective in treating conditions with high proinflammatory characteristics, such as osteoarthritis and wound healing, than in skin rejuvenation. Centrifugation is identified as the most effective method for tSVF isolation. The review highlights the need for standardized procedures and further research to optimize tSVF isolation techniques, noting the variability in outcomes and the absence of a superior method due to differing study designs and endpoints.

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