Mechanical Fractionation of Adipose Tissue: A Scoping Review of Procedures to Obtain Stromal Vascular Fraction

This scoping review evaluates the efficacy of mechanical fractionation procedures to obtain tissue stromal vascular fraction (tSVF) from adipose tissue, highlighting its therapeutic potential in regenerative medicine. The review categorizes mechanical fractionation methods into filtration, centrifugation, and combinations thereof, analyzing data from 1,465 patients and 410 animals. Findings suggest that tSVF is particularly effective in treating conditions with high proinflammatory characteristics, such as osteoarthritis and wound healing, compared to skin rejuvenation. Centrifugation prior to mechanical fractionation is noted as the most effective method for isolating tSVF by reducing volume. The study concludes that tSVF's clinical benefits are consistent across different preparation methods, underscoring the versatility of current techniques.