Concentrated Nanofat: A Modified Fat Extraction Promotes Hair Growth in Mice via Stem Cells and Extracellular Matrix Components Interaction

In the study by Li et al., concentrated nanofat (CNF) was shown to effectively promote hair growth in mice, more so than adipose-derived stem cells (ADSCs) alone. The research involved injecting CNF, decellularized CNF (DCNF), and ADSCs into mice and observing hair growth effects. High doses of ADSCs and CNF were effective in promoting hair growth, while low doses of ADSCs and DCNF alone were not; however, a combination of the two at low doses did promote hair growth. In vitro, CNF-conditioned media (CM) increased proliferation, migration, and cell cycle progression in dermal papilla cells (DPCs), and elevated Wnt/ß-catenin pathway protein levels. The study concluded that CNF has a superior effect on hair growth by activating DPCs and inducing the anagen phase, with the ECM significantly enhancing the effects of ADSCs, providing a basis for CNF's clinical application in treating hair loss.